Invest alongside the operators.
Protosome builds, acquires, and runs companies with an AI-native operating stack. The Syndicate lets you back those companies deal by deal, on the same terms we take ourselves. No fund, no capital call, no obligation until you say yes to a specific deal.
Companies that get cheaper to run every year.
Operator-led, not spectator capital
Every deal we share is one we are building, buying, or operating ourselves. You see the same diligence pack we use to decide, and you invest on the same terms as Protosome.
Agent-run operations
Our edge is the operating stack: a fleet of AI agents that runs back office, content, and growth across the portfolio. We target businesses where that stack replaces real cost lines, not hypothetical ones.
Healthcare first, not healthcare only
Our deepest lane is healthcare and wellness, from telehealth brands to practice back office. The Syndicate also sees vertical software, media, and services deals where the same playbook applies.
Built to be bought
We underwrite with the exit in mind. Protosome Advisory runs sell-side processes for founders, and we apply that buyer's lens to every company before we commit a dollar.
Deal by deal. Opt in when it fits.
Joining the Syndicate costs nothing and commits you to nothing. It puts you on the list for the deals we share.
Apply on AngelList
Request to join the Protosome Syndicate on AngelList. You will need to confirm accredited investor status, as required by the SEC for private placements.
Receive deal memos
When we commit to a company, members get the memo: the thesis, the numbers, our own payback math, what the agent stack replaces, and the risks we see.
Invest on your terms
Decide per deal. Minimums and allocations vary by opportunity and are stated in each memo. Pass on anything that does not fit.
Follow the operating story
Members get operating updates on the companies they backed, written by the people running them, with the KPIs we hold ourselves to.
Led by the people running the companies.
George Georgallides
Founder, Protosome
Builds, acquires, and operates healthcare and technology companies. Runs Protosome's portfolio on an AI-native operating stack and leads sell-side mandates through Protosome Advisory.
- Vehicle
- AngelList syndicate, one SPV per deal
- Commitment
- None to join. Opt in per deal.
- Eligibility
- Accredited investors (SEC Rule 501)
- Check size
- Stated per deal in each memo
Companies we build and operate today.
Protosome's operating portfolio spans healthcare, software, consumer, and culture. Syndicate deals are drawn from this pipeline and shared one at a time.
Healthcare software
Basis / Ready Practice
AI-native practice management and back office for independent practices.
Consumer healthcare
Telehealth brands
A portfolio of specialty telehealth brands built on shared infrastructure.
Consumer wellness
Dr Sebi's
Heritage wellness brand with a global product line and community.
Culture and collectibles
Nearta
Collection, community, and market intelligence for collectors.
Before you apply.
- Is there a fee to join?
- No. Joining puts you on the list. Economics for each deal, including any carry, are disclosed in that deal's memo on AngelList.
- How often do deals come through?
- Only when we commit. We would rather share four deals a year we are operating than forty we are not.
- Do I have to be in the US?
- No, but you must meet AngelList's investor requirements for your jurisdiction and accredited status under SEC rules.
- Can I invest in Protosome itself?
- The Syndicate is for individual portfolio companies. If you are interested in Protosome at the holding level, email partnerships@protosome.com.
Back the companies we run.
Join the Syndicate to see the next deal memo. Accredited investors only. Nothing here is an offer to sell securities; offers are made only through AngelList to eligible members.